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Lattari E, Paes F, Machado A, Rocha NBF, Nardi AE, Machado S. Chronic effects of aerobic exercise on panic disorder: a systematic review of randomized and non-randomized trials. MEDICALEXPRESS 2015;2(6):M150602



Chronic effects of aerobic exercise on panic disorder: a systematic review of randomized and non-randomized trials

Eduardo Lattari1; Flávia Paes1; Ana Machado2; Nuno Barbosa Ferreira Rocha2; Antônio Egidio Nardi1; Sérgio Machado1,3

1. Universidade Federal do Rio de Janeiro, Instituto de Psiquiatria, Laboratório de Pânico e Respiração, Rio de Janeiro, Brasil
2. Instituto Politécnico do Porto, Escola Superior de Tecnologia da Saúde, Porto, Portugal
3. Universidade Salgado de Oliveira, Programa de Pós-Graduação em Ciência da Atividade Física, Laboratório de Neurociência da Atividade Física, Niterói, Brasil


Received in October 18 2015.
First Review in October 22 2015.
Accepted in October 31 2015.


BACKGROUND: In general, most studies have supported an association between the acute effects of exercise and a reduced state anxiety, but failed to completely explain the relationship between the chronic effect of exercise and anxiety traits.
OBJECTIVE: The aim of this study was to systematically review the literature regarding the chronic effect of exercise on symptoms associated with panic disorder.
METHODS: The studies were retrieved from a MEDLINE/PubMed, ISI Web of Knowledge and SciELO. We adopted PICOS's strategy recommended to determine the eligibility criteria. The survey was conducted using an advanced search in the ISI Web of Science and MEDLINE / PubMed with MeSH terms and Entry Terms for the keywords "Panic Disorder" basis and "Exercise". Boolean operators "AND" and "OR" were used separately or in combination. Two independent researchers performed the selection of studies; in case of disagreement they sought a consensus on the selection.
RESULTS: A total of 265 articles were identified: 199 articles from PubMed/Medline, 63 articles from ISI Web of Science and 3 articles by manual searches. Thus, 31 articles were analyzed by the eligibility criteria and the exclusion criteria, a total of five studies included in the systematic review.
CONCLUSION: The regular practice of aerobic exercise seems to be an appropriate intervention to promote improvements in the severity of anxiety symptoms in PD patients.

Keywords: Chronic effects, Aerobic exercise, Panic disorder.


INTRODUÇÃO: Em geral, grande parte dos estudos indicam a existência de uma associação entre os efeitos agudos do exercício aeróbio e um estado de ansiedade reduzida; no entanto, estes estudos não conseguem elucidar completamente a relação entre o efeito crônico do exercício aeróbio e traços de ansiedade.
OBJETIVO: O objetivo deste estudo foi revisar sistematicamente a literatura sobre o efeito crônico do exercício sobre sintomas associados com transtorno do pânico.
MÉTODOS: Os estudos foram recuperados de: MEDLINE/PubMed, ISI Web of Knowledge e SciELO. Adotamos a estratégia PICOS para determinar os critérios de elegibilidade. A estratégia de busca foi realizada utilizando uma pesquisa avançada no ISI Web of Science, MEDLINE/PubMed e SciELO com os seguintes termos: "Transtorno de Pânico" e "Exercício". Operadores booleanos AND e OR foram utilizados para combinação dos termos. A seleção dos estudos foi realizada por dois pesquisadores independentes que, em caso de desacordo, procuraram um consenso sobre a seleção.
RESULTADOS: Foram identificados um total de 265 artigos: 199 artigos do PubMed/Medline, 63 artigos do ISI Web of Science e 3 artigos através de pesquisas manuais. Assim, 31 artigos foram analisados pelos critérios de elegibilidade e os critérios de exclusão, sendo que um total de cinco estudos foram incluídos na revisão sistemática.
CONCLUSÃO: A prática regular de exercício aeróbio parece ser uma intervenção apropriada para promover a melhoria da gravidade dos sintomas de ansiedade em pacientes com transtorno de pânico.

Palavras-chave: Efeitos crônicos, exercício aeróbio, transtorno do pânico.



Panic disorder (PD) is characterized by the presence of recurrent panic attacks, with at least one of them being sudden and followed by at least one month of persistent concern about a new attack or concerns about its effects.1

Epidemiological data is scarce regarding the prevalence and incidence of PD, perhaps because until the nineteen eighties, the diagnosis of people suffering from anxiety attacks was anxiety neurosis. PD is about twice as common in women as it is in men (DSM-V) and usually begins in late adolescence or early adulthood, with an average onset between 20 and 30 years.1 Long term PD is associated with a decrease in productivity, well-being, social contact and self-realization.2 In addition, comorbidities such as chest pain,3 coronary artery disease4 and other psychiatric comorbidities such as depression,5 substance abuse and suicide are common in these patients.6 In a review by Konnopka et al.7 it was found that most of the costs related with and anxiety disorders and their treatment were linked to PD and generalized anxiety disorder.

The most common forms of treatment in PD patients are pharmacotherapy and cognitive-behavioral therapy (CBT). In the acute phase of treatment, the combination of antidepressants and CBT appears to have better outcomes than the isolated treatment with either antidepressant or psychotherapy. The combined treatment gains seem to endure when compared to either monotherapy given alone. However, combined therapy may result in more dropouts than psychotherapy because of side effects.8 Despite the assumed superiority of combined therapy, no difference was found after seven months of interruption between a combination of benzodiazepine with CBT vs. the isolated use of CBT.9 Furthermore, although patients with PD present good pharmacological responses to treatment, approximately 20% of them remain symptomatic.10

Due to the chronic nature of anxiety disorders, new treatment strategies are being introduced, one of which is the use of physical exercise. Consequently, a growing number of studies have used exercise as a possible strategy to reduce anxiety. It seems that exercise is anxiolytic both for healthy subjects and for patients with PD, but, at the same time, it can induce panic attacks in these patients.11 The possibility of physical exercise causing the patient to experience some symptoms of panic attack causes these individuals to avoid it and to exhibit low tolerance while exercising.12,13 This can be troubling, because some research has shown the anxiolytic effects of exercise, both acutely11,14 and chronically.13,15 Acutely, exercise seems to have an antipanic and anxiolytic protective effect in patients who are subjected to carbon dioxide inhalation14 and administration of cholecystokinin tetrapeptide.11 This is possibly explained by the fact that the acute exposition to exercise increases the plasma concentration of atrial natriuretic peptide, which is know to have ansiolytic efffects.16 However, few studies support the hypothesis that physical exercise has chronic anxiolytic effects.13,17 For example, in the study by Meyer et al,13 it has been demonstrated that aerobic exercise compared to placebo condition provided anxiolytic effects in the 6th and 10th week of treatment. However, some interpretations of the chronic effects of exercise may be inaccurate. This can be seen in the study published by Wedekind et al,18 where only the fourth week of the exercise intervention showed improvements in the Panic Agoraphobia Scale, compared to the condition without exercise. Nonetheless, this improvement may have been derived from the use of paroxetine, which improves outcome (as measured by the Panic Agoraphobia Scale) when compared with placebo and independently of exercise.

In general, most studies have supported an association between the acute effects of exercise and a reduced state of anxiety, but failed to completely explain the relationship between the chronic effect of exercise, physical fitness and anxiety traits.19 The short duration of the studies and the inconsistency in the selection of patients with PD regarding adequate diagnosis weakens the results of several studies. The use of different anxiety measurements can further limit the generalizability of their findings. Moreover, the lack of valid control groups also occurs. Finally, for some disorders, such as PD, exercise can be helpful as a therapeutic alternative or add-on for the treatment of anxiety disorders.20

The aim of this study was to systematically review the literature regarding the chronic effect of exercise on anxiety symptoms associated with PD. Although a consistent association between exercise and anxiety levels has been described, most authors emphasize that the causal effect of exercise decreasing anxiety is yet to be supported.



Eligibility Criteria

We adopted PICOS's strategy ("Population", "Intervention", "Comparators", "Outcomes" and "Study design") recommended to determine the eligibility criteria.

1. Population: men and women, physically active or not, diagnosed with PD, according to DSM (III, IV and V) and to the tenth edition of the International Classification of Diseases (ICD-10), with or without other comorbidities associated.

2. Intervention: participants subjected to a chronic aerobic exercise intervention, associated or not with the use of drugs and other therapies (cognitive behavioral therapy).

3. Comparators: existence of a control group (placebo), which did not receive an aerobic exercise intervention for comparison purposes.

4. Outcomes: measurements that assess symptoms of PD included. These had to be divided into scales that assess global anxiety, frequency and intensity of panic attacks, phobic avoidance and cognitive distortions in relation to physical reactions of anxiety;

5. Study design: randomized controlled trials and non-randomized studies used to evaluate the chronic effect of exercise on symptoms of panic.

Exclusion Criteria

We excluded studies without any aerobic exercise intervention and/or without detailed statistical procedures and results of study outcome. The articles were not published in English were also excluded.


The studies were retrieved from MEDLINE/PubMed, ISI Web of Knowledge and SciELO. Experts on the subject of the present study were also contacted to indicate articles. To find additional articles, all tables in retrieved articles were examined for evidence of previous systematic reviews; references to randomized controlled trials were examined. In addition, we analyzed the references of all selected articles. Searches were closed on the 15th of October of 2014.


The survey was conducted using an advanced search in the ISI Web of Science and MEDLINE/PubMed with MeSH terms and Entry Terms for the keywords "Panic Disorder" basis and "Exercise". Boolean operators AND and OR were used in the following combinations: "Disorder", "Panic" OR "Disorders", "Panic" OR "Panic Disorders" OR "Panic Attacks" OR "Attack", "Panic" OR "Attacks", "Panic" OR "Panic Attack" AND "Exercises" OR "Exercise", "Physical" OR "Exercises", "Physical" OR "Physical Exercise" OR "Physical Exercises" OR "Exercise", "Aerobic" OR "Aerobic Exercises" OR "Exercises", "Aerobic" OR "Aerobic Exercise". All combinations necessary for the search were performed in SciELO database.

Selection of studies

Two independent researchers performed the selection of studies; in case of disagreement they sought a consensus on the selection. The evaluation consisted of a selection of studies by analysis of the title, followed by analysis of the abstract and then the analysis of the full text. When disagreement between the two researchers persisted, a third evaluator was called in to complete the process. Relevant articles were obtained and assessed for eligibility and exclusion criteria described in the methods.

Data collection

The data collected from the study were: numbers of participants, age, treatment performed, medication, study duration, frequency, duration and intensity of exercise, supervision in different treatments, diagnostic criteria and severity of the disease, instruments assessment, comorbidities, randomization of subjects and main results.



A total of 265 articles were identified: 199 articles from PubMed/Medline, 63 articles from ISI Web of Science and 3 articles by manual searches. No article was identified from ScieLO. After the duplicates were removed (n = 10), 255 articles were analyzed by title and/or abstract. After this analysis, 224 articles were removed for not corresponding to the studied topic. Thus, 31 articles were analyzed through the eligibility criteria, according to the model proposed by the "Prisma" and through the exclusion criteria. A total of five studies were included in the systematic review as shown in Figure 1.


Figure 1- Flow of information through the different phases of Study selection


The treatments used in the five articles selected for systematic review were: CBT, drugs, physical exercise and control condition. The use of healthy individuals, educational programs, and relaxation exercises were used as a means of control; moreover, placebo pills was also used as controls. The drugs used in the treatment intervention during the studies were clomipramine15 and paroxetine.18

In one study it was reported that patients received benzodiazepines and selective serotonin reuptake inhibitors;17 two studies reported the use of promethazine in cases of panic attack.15,18 One study noted that the patients did not use medication during treatment19 and another study made no mention about the use of drugs during interventions.21 The treatment time ranged from eight to twelve weeks, except for one in which the follow-up period ranged from six to twelve months.17

On average, aerobic exercise was prescribed three times a week, between 30 and 60 minutes of total time. However, the intensities are not well established. In one study, subjects were instructed to keep a percentage of maximum heart rate (60% - 80% HRmax)17 and in another a percentage of 70% of maximum oxygen consumption (VO2max).18

All interventions with CBT were administered by clinical psychologists with experience. Nevertheless, physical trainers,15,18,21 an experienced runner,13 physical therapists, occupational therapists and nurses17 supervised the interventions with physical exercise.

The diagnoses for panic disorder were conducted according to DSM-III, DSM-IV and ICD-10. Only two studies reported the values for the severity of PD.18,21

For the assessment of PD the following instruments were used: "Mobile Inventory", "Agoraphobic Cognitions Questionnaire", "Body Sensations Questionnaire", "Hamilton Anxiety Scale," "Panic and Agoraphobia Scale" and "Depression Anxiety Stress Scale".

Regarding the type of study, all the studies were randomized, with variability in control conditions, including the use of a placebo, of educational programs, or the absence of exercise or healthy subjects.

For the main outcomes, results were quite contradictory (see Table 1), as it will be explained in the discussion.




The aim of this study was to review systematically, the chronic effect of exercise on anxiety symptoms in associated with PD.

Data from our review showed some conflicting results. For example, in a recent study published in 2012, by Hovland et al,17 treatment with exercise provided a significant improvement in cognition (catastrophic thoughts associated with panic attack), physical symptoms and severity of agoraphobic avoidance, respectively measured by "Agoraphobic Cognitions Questionnaire", "Body Sensations Questionnaire" and "Mobile Inventory". However, with CBT better responses were obtained in cognition and physical symptoms.

The Wedekind et al.18 study compared treatment with aerobic exercise, with or without the use of drugs (paroxetine), with a control condition (relaxation), associated or not with paroxetine. The use of paroxetine was the key to the improved responses relating to anxiety. Indeed, in the fourth week of intervention, the group that performed aerobic exercise was superior compared to relaxation group. Considering that the difference in treatment occurred only after 4 weeks, it should be noted that the improvement might have been caused by the effect of the drug itself.

Corroborating these concepts, another survey, conducted by Broocks et al.15 compared three groups (aerobic exercise, clomipramine and placebo) for 10 weeks of intervention on the severity of PD with or without agoraphobia. Using the "Agoraphobia and Panic Scale", and the "Hamilton Anxiety Scale", the results showed that clomipramine was always superior to placebo and exercise conditions. Despite the superiority of clomipramine, aerobic exercise was superior to placebo condition. Thus, aerobic exercise alone may have some anxiolytic effect in PD patients in this study.

The hypothesis that aerobic exercise promotes anxiolytic effects has been corroborated in studies with acute PD patients.11,14 The explanation for this phenomenon may be associated to some acute physiological and behavioral changes caused by aerobic exercise. One suggestion relates to the fact that exercise increases the levels of atrial natriuretic peptide (anxiolytic action) and promote anti-panic actions.11,14 Aerobic exercise has been shown to reduce generalized anxiety and may also reduce anxiety sensitivity.22 The anxiety sensitivity is a precursor of panic attacks and PD.23 Taking this into account, protocols of 20 minutes of aerobic exercise with moderate (60% of HRmax) or high intensity (90% of HRmax) were performed, which caused reductions in the sensitivity to anxiety in both cases. However, the high-intensity exercise caused more abrupt reductions of a global measure of anxiety sensitivity.22 Thereby, it has been speculated that continuous exposure to aerobic exercise leads to a decrease in anxiety sensitivity, a fact observed in another study,24 in which the active lifestyle in PD patients showed lower anxiety sensitivity.

On this basis, it appears that to provide the opportunity for PD patients to participate in regular aerobic exercise programs may be beneficial with regard to the severity of the disorder.

In spite of the lower effectiveness of exercise compared with clomipramine, aerobic exercise was better than control conditions in ten weeks of aerobic training.15 Using an aerobic training protocol (outdoor running) for 10 weeks (four miles, three or four times a week), significant improvements in specific scales that assess the severity of PD ("Panic and Agoraphobia Scale" and the "Hamilton Anxiety Scale") were reported.13 Meyer et al. also demonstrated that PD patients who performed aerobic exercise, when compared to control and placebo groups, had reductions in anxiety scores in the sixth and tenth weeks.13 However, in contrast to the evidence showing that aerobic exercises can produce anxiolytic effects in PD patients, another study did not show such improvements: Merom et al21 compared a CBT intervention associated with aerobic exercise versus a CBT intervention associated with educational programs. The educational programs functioned as a control group, in which the subjects received information on healthy eating habits. These results showed that exercise had no influence on improvement of stress, anxiety and depression.

An important point in chronic studies of aerobic exercise with PD patients is the inadequate standardization of training prescriptions. According to our analysis, the control of the intensity, duration and frequency of training is not adequate. In addition, in two studies included in our review,13,17 there was no participation of a physical trainer in directing the training prescription. Thus, the lack of a structured protocol for prescribing aerobic training may be crucial to the adverse results. A case report showed that an effort interspersing two minutes of slow walking (73% of HRmax) with two minutes of brisk walking (83% of maximum heart rate), consisting of 12 training sessions, causes a reduction in cardiac anxiety.25 In another study published by Broman-Fulks et al,23 it has been shown that aerobic exercise performed in six sessions, for 20 minutes at an intensity of 70% of HRmax was sufficient to decrease the anxiety sensitivity, when compared to conditions without exercise. We therefore suggest that a greater control in the aerobic exercise prescription, may bring responses that may clarify the effectiveness of exercise on PD symptoms.



The regular practice of aerobic exercise seems to be an appropriate intervention to promote improvements in the severity of anxiety symptoms in PD patients. However, the clinical trials reviewed here have shown a lack of adequate exercise prescription for this population. Therefore, we strongly believe that a greater level of standardization of standardization in the aerobic exercise prescription, a correct diagnosis of PD and an adequate assessment of the severity of PD in randomized controlled clinical trials, should produce better responses regarding the effectiveness of exercise on symptoms PD.



Eduardo Lattari thanks to Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil.



The authors state none conflict of interest



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