Medical Express

ISSN (print): 2318-8111

ISSN (online): 2358-0429

Author's Articles

2 result(s) for: Suzana Monteiro

Working memory dysfunction in insomniac adults: a systematic metanalytical review

Bárbara Monteiro; Maristela Candida; Suzana Monteiro; Flávia Paes; Ti-Fei Yuan; Ang Li; Xin Sun; Nuno Barbosa F. Rocha; Carlos Campos; Antonio Egidio Nardi; Sergio Machado

MEDICALEXPRESS 2016;3(2):M160202 - REVIEW

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BACKGROUND: Insomnia is the most commonly occurring sleep disorder: recent reports estimate that 25-30% of adults in the general population occasional instances of experience insomnia, while 10% suffer from disturbances severe enough to meet diagnostic criteria for insomnia. Little is known about the mechanisms, causes, clinical course, and consequences of this condition. Over 30 studies have been published on the matter but only a small proportion has found differences in the working memory of individuals with vs. without insomnia.
OBJECTIVE: To summarize evidence regarding the differences in working memory performance between insomniac vs. normal adult sleepers.
METHODS: The survey was conducted using an advanced search in the ISI Web of Science and MEDLINE/PubMed with the terms "sleep", "insomnia" and "working memory" as major descriptors; these were crossed with the following keywords: "psychological tests", "neuropsychology" and "performance".
RESULTS: A total of 112 articles were identified in the search conducted in PubMed and Web of Science. After the screening, 102 articles unrelated to the proposed theme were excluded. Thus, 10 articles were analyzed by the eligibility and exclusion criteria, and included in this systematic review.
CONCLUSION: The information resulting from the analysis of the reviewed articles suggests that mild, but not definitive deficits in cognitive performance might be masked by insignificant disparities in studies comparing insomniac individuals with normal sleepers. This shortcoming can be circumvented by larger and better-characterized samples, together with optimized methodological control of factors which might otherwise result in confounding variations among participants.



Keywords: Insomnia, working memory, cognitive performance.

Association between depression severity and executive functioning in late-life depression: a systematic review

Suzana Monteiro; Bárbara Monteiro; Maristela Candida; Nathalia Adler; Carlos Campos; Nuno Barbosa F. Rocha; Flávia Paes; Antônio Egidio Nardi; Sergio Machado

MEDICALEXPRESS 2016;3(6):M160601 - REVIEW

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OBJECTIVE: Late-life depression is an under-diagnosed and under-treated disease that reduces the well-being of older adults. Executive dysfunction is another critical impairment in elderly depressed individuals which further disrupts their everyday functioning. This systematic review aims to analyze the association between executive function and depression severity in elderly individuals diagnosed with major depressive disorder.
METHOD: The studies were retrieved from MEDLINE/PubMed, ISI Web of Knowledge and PsychInfo, after a search strategy combining the terms "depression", "executive function", "neuropsychological assessment", "elderly" and "late life". Study selection, data collection and quality ratings was performed by two independent raters.
RESULTS: A total of 1,130 articles were found but only 8 studies met the defined eligibility criteria and evaluated the association between depression severity and executive functioning. Six out of 8 studies found an association between depression severity and executive function, with correlations ranging from small to large (r= -0.15 to -0.53). The included reports had several methodological limitations such as selective data reporting, non-comprehensive executive function assessment and not controlling potential biases.
CONCLUSION: Depression severity may be more strongly correlated with a specific set of executive abilities although it also seems to be a broad-based association with executive functioning as a whole. Future high-quality prospective studies are recommended in order to understand the causal relationship between depression severity and executive functioning taking into account possible mediators such as age-related or neurodegenerative cognitive impairment, educational level and other clinic characteristics (e.g. age of onset, medication).



Keywords: Late-life Depression, Major Depressive Disorder, Executive Function.